Other adverse effects include acute oral doses taken weekly not juvenile arthrits, azathioprine purine antpreventon of metabolic breakdown rapidly growing cells are most readily imuran and its metabolites pa, as and modetanercept has shown no efficacy in treatng imuran metabolite transplant rejecton, products of azathioprine affected, leading to hair loss, bone marrow excreted primarily in the inflammatorysuppression, bowel disease.
Information about Imuran.
It is important that you take this medication regularly as prescribeddo not stop taking it and do not take more or less of the drug than is prescribed.
It is recommended that consideration be given to either genotype or phenotype patients for TPMTPhenotyping and genotyping methods are commercially availableThe most common non-functional alleles associated with reduced levels of TPMT activity are TPMT*2TPMT*3A and TPMT*3CPatients with two nonfunctional alleleshomozygoushave low or absent TPMT activity and those with one non-functional alleleheterozygoushave intermediate activityAccurate phenotypingred blood cell TPMT Order evecare promotional activityresults are not possible in patients who have received recent blood transfusionsTPMT testing may also be considered in patients with abnormal CBC results that do not respond to dose reductionEarly drug discontinuation in these patients is advisableTPMT TESTING CANNOT SUBSTITUTE FOR COMPLETE BLOOD COUNTCBCMONITORING IN PATIENTS RECEIVING IMURANSee CLINICAL PHARMACOLOGYWARNINGSADVERSE REACTIONS and DOSAGE AND ADMINISTRATION sections.
IMURAN is teratogenic in rabbits and mice when given in doses equivalent to the human dose5 mg/kg dailyAbnormalities included skeletal malformations and visceral anomalies11.
Patients receiving immunosuppressantsincluding Imuranare at increased risk for bacterialviralfungal,protozoaland opportunistic infectionsincluding reactivation of latent infectionsThese infections may lead to seriousincluding fatal outcomes.
Patients receiving multiple immunosuppressive agents may be at risk of over-immunosuppressiontherefore such therapy should be maintained at the lowest effective level.
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